Arsene Wenger has opted to start Olivier Giroud as the striker while Jack Wilshere starts for Arsenal as they take on West Ham United.
David Moyes and his West Ham United side will be eager to win their second London derby in a row as they prepare to host Arsenal on Wednesday.
Chelsea make the short 10-mile journey east to take on fierce rivals West Ham United in a bid to keep their winning momentum going
Wayne Rooney brought a sprinkle of nostalgia in the hearts of Manchester United fans worldwide with a hattrick for Everton in a 4-0 win over West Ham United.
Tottenham are reportedly monitoring Manuel Lanzini's situation at West Ham United, with other Premier League clubs also interested in the Argentine
Ronald Koeman is reportedly targeting a January move for West Ham striker Andy Carroll, which could see the former Liverpool man move back to Merseyside.
Old Trafford will brace itself for the return of Chicharito while Jose Mourinho has handed starts to Romelu Lukaku and Nemanja Matic
Jose Mourinho will have a full squad of players to choose from barring Luke Shaw, Marcos Rojo and Ashley Young as West Ham travel to Old Trafford
Liverpool and West Ham are reportedly interested in signing 26-year-old Benfica forward Raul Jimenez this summer
West Ham are reportedly considering a move to bring Javier Hernandez back to England and are prepared to meet the player's £13 million release clause.