One of the four semi-finalists of the UEFA Europa League will be confirmed when Valencia host Villarreal at Mestalla in the quarter-final second leg on Thursday.
In what will be an all-Spanish encounter, Villarreal will take on Valencia in the first leg of their UEFA Europa League quarter-final tie on Thursday night.
Real Madrid produced a listless performance to be defeated for the first time since Zinedine Zidane returned as Valencia beat them 2-1 at Mestalla.
Real Madrid suffered their first defeat since the return of Zinedine Zidane, with Karim Benzema scoring a late consolation goal in a 2-1 loss to Valencia.
Luka Modric and Toni Kroos are among a number of players set to return when Real Madrid take on Valencia at the Mestalla on Wednesday night.
Real Madrid will be aiming to continue keeping pace with Atletico Madrid when they pay Valencia a visit at the Mestalla on Wednesday night.
Lionel Messi brought Barcelona back from two goals down against Valencia as the two sides played out a pulsating 2-2 draw at Camp Nou on Saturday.
Sergio Busquets will be one of five players missing out for Barcelona as they get set to welcome Valencia to Camp Nou in a Matchday 22 tie on Saturday.
Barcelona will be aiming to stretch their lead on top of the La Liga table when they welcome Valencia to Camp Nou on Saturday evening.
A Carlos Soler strike and an own goal from Phil Jones condemned Manchester United to a defeat against Valencia on Wednesday night.