Henrikh Mkhitaryan returns to the squad ahead of Anthony Martial, with Jesse Lingard and Marcus Rashford retaining their place in the starting XI after their last match against Swansea. Marouane Fellaini will partner Ander Herrera and Paul Pogba in United's midfield.
The Biaconeri, led by Massimiliano Allegri recorded a superb victory against dark horses Monaco in the the first leg of the Champions League semi-final and the Italian got his tactics spot on against Leonardo Jardim's exciting young side.
Juventus outclassed Barcelona at Camp Nou and restricted them to a goal-less draw, thus qualifying to the semi-finals on the basis of aggregate goals.
Borussia Dortmund will travel to Monaco for their second-leg quarter final match, as they hope to reverse the aggregate score of 3-2.
It was a second half filled with drama at the The King Baudouin Stadium as an 89th minute Romelu Lukaku equalizer amidst 2 Greek players getting sent off ensured that the match ended 1-1 and that Belgium kept their place atop Group H.
The Hard Tackle takes a look at some of the key moments in what was a near-perfect 2016 for European Champions Real Madrid
The Hard Tackle takes a look at some of the key stories regarding Barcelona from the day.
On Monday, UEFA revealed their 40-man shortlist for the Team of the Year for 2016
Zlatan Ibrahimovic could be facing a retrospective ban for violent conduct after he appeared to choke Simon Kjaer in Manchester United's defeat to Fenerbahce on Thursday.
Manchester City's 3-1 win over the Catalan giants will go down as one of the most historic nights for the club and could be a victory that spurs the Citizens on in Europe.