Toni Kroos and Casemiro will return to the lineup while Marco Asensio will still not be fit enough to start when Real Madrid take on Espanyol.
Bayern Munich are reportedly interested in re-signing Toni Kroos from Real Madrid in the summer transfer window.
Toni Kroos is likely to replace Luka Modric while Marcelo will return to the starting lineup when Real Madrid take on Barcelona on Sunday.
Toni Kroos and Eden Hazard impressed while Gareth Bale struggled again as Real Madrid were held to a 2-2 draw by relegation battlers Celta Vigo on Sunday night.
Thibaut Courtois came to Real Madrid's rescue as they beat Atletico Madrid 4-1 on penalties to lift the Spanish Super Cup on Sunday.
Zinedine Zidane and Diego Simeone's men will meet in an epic Madrid Derby finale miles away from Spain in Saudi Arabia.
Toni Kroos is set to return while Gareth Bale will likely replace Rodrygo Goes when Real Madrid take on Valencia at the Mestalla on Sunday.
Eder Militao was colossal at the back, while Toni Kroos ran the show as Real Madrid narrowly beat Alaves 2-1 at the Mendizorrotza on Saturday.
Sergio Ramos nearly went from hero to zero before Dani Carvajal struck an open goal to ensure a 2-1 win for Real Madrid over Alaves at the Mendizorrotza.
A first half Toni Kroos goal was enough to hand Real Madrid all three points as they beat Galatasaray 1-0 to grab their first Champions League win of the season.