We preview Friday night's key Serie A clash between Napoli and Inter Milan
Arsene Wenger is likely to field some academy graduates as Arsenal face Southampton in EFL Cup tie.
Arsenal host Bournemouth at the Emirates on Sunday in a bid to continue their run of 18 games without defeat and stay within touching distance of league leaders Chelsea.
Chelsea will be keen to continue their rampant form in the league and have further options to choose from with the return of John Terry, Cesc Fabregas and Kurt Zouma. However boss Antonio Conte confirmed that only Terry is in line for selection.
Jose Mourinho has taken a 21-man squad to Turkey with Manchester United facing off against Fenerbahce in a crucial Europa League tie at the Ulker Stadium on Thursday.
Liverpool will be buoyed by the returns of Georginio Wijnaldum, Adam Lallana and James Milner from injury and are likely to name a full-strength side in a bid to keep pressure on the leaders in the Premier League.
FC Barcelona look set to welcome Lionel Messi back into the mix following the Argentines recovery from injury that kept him out of action for three weeks.
Arsenal have no fresh injury worries for their trip to Burnley on Sunday, but will continue to miss the services of Olivier Giroud and Aaron Ramsey.
Manchester United will be looking to continue their two-game winning run when they play host to Ukrainian side Zorya Luhansk in the Europa League on Thursday.
After playing three games in eight days last week, Jose Mourinho is set to give a number of first-team players a breather for the game against Northampton.