Liverpool will be buoyed by the returns of Georginio Wijnaldum, Adam Lallana and James Milner from injury and are likely to name a full-strength side in a bid to keep pressure on the leaders in the Premier League.
FC Barcelona look set to welcome Lionel Messi back into the mix following the Argentines recovery from injury that kept him out of action for three weeks.
Arsenal have no fresh injury worries for their trip to Burnley on Sunday, but will continue to miss the services of Olivier Giroud and Aaron Ramsey.
Manchester United will be looking to continue their two-game winning run when they play host to Ukrainian side Zorya Luhansk in the Europa League on Thursday.
After playing three games in eight days last week, Jose Mourinho is set to give a number of first-team players a breather for the game against Northampton.
In what is the marquee clash of the competition, France and Germany lock horns at Marseille as the European heavyweights fight for a spot in the final against Portugal. While Joachim Low has a selection head-ache, Didier Deschamps has a tactical dilemma to sort out ahead of the big clash on Thursday.
Sitting with a nine point lead at the top of the table, the Catalans are eyeing a second successive treble while Real have their sight firmly fixed on the Champions League trophy after dropping out of the title race.
While Barcelona do not have any serious injury concerns ahead of their clash against Real Madrid, defenders Jeremy Mathieu and Adriano are expected to be unavailable for the fixture.
With Borussia Dortmund all but through to the Europa League quarter-finals following last week's 3-0 win over Tottenham Hotspur, manager Thomas Tuchel was full of praise for his counterpart, claiming that 'success is coming' for the North London side.
Speaking ahead of Tottenham Hotspur's Europa League Round of 16 second-leg clash against Borussia Dortmund, Mauricio Pochettino claimed that his side is ready to ‘dream’ again after Dortmund ‘accident’.