In tonight's London Derby, Chelsea travel to the london Stadium to face Slaven Bilic's West Ham United as they look to reclaim their 10 point lead at the top of the table.
Real Madrid travel to the Castellon province to face Villarreal CF and Zinedine Zidane provided some updates regarding Bale's return to fitness and Varane's injury
Antonio Conte has a full strength squad to choose from as he prepares his side for an in-form Burnley side at Turf Moor, and the Italian addressed the possibility of rotating key players in attacking positions.
In their pursuit of a third consecutive victory, Manchester United are set to receive a massive boost in the form of a return to action for Chris Smalling who hasn't featured since his side's 4-0 loss to Chelsea almost two months ago.
All the team news ahead of FC Barcelona's clash against Osasuna
We take a look at the team news for Arsenal ahead of their final Champions League group stage fixture against FC Basel
We preview Friday night's key Serie A clash between Napoli and Inter Milan
Arsene Wenger is likely to field some academy graduates as Arsenal face Southampton in EFL Cup tie.
Arsenal host Bournemouth at the Emirates on Sunday in a bid to continue their run of 18 games without defeat and stay within touching distance of league leaders Chelsea.
Chelsea will be keen to continue their rampant form in the league and have further options to choose from with the return of John Terry, Cesc Fabregas and Kurt Zouma. However boss Antonio Conte confirmed that only Terry is in line for selection.