In their pursuit of a third consecutive victory, Manchester United are set to receive a massive boost in the form of a return to action for Chris Smalling who hasn't featured since his side's 4-0 loss to Chelsea almost two months ago.
All the team news ahead of FC Barcelona's clash against Osasuna
We take a look at the team news for Arsenal ahead of their final Champions League group stage fixture against FC Basel
We preview Friday night's key Serie A clash between Napoli and Inter Milan
Arsene Wenger is likely to field some academy graduates as Arsenal face Southampton in EFL Cup tie.
Arsenal host Bournemouth at the Emirates on Sunday in a bid to continue their run of 18 games without defeat and stay within touching distance of league leaders Chelsea.
Chelsea will be keen to continue their rampant form in the league and have further options to choose from with the return of John Terry, Cesc Fabregas and Kurt Zouma. However boss Antonio Conte confirmed that only Terry is in line for selection.
Jose Mourinho has taken a 21-man squad to Turkey with Manchester United facing off against Fenerbahce in a crucial Europa League tie at the Ulker Stadium on Thursday.
Liverpool will be buoyed by the returns of Georginio Wijnaldum, Adam Lallana and James Milner from injury and are likely to name a full-strength side in a bid to keep pressure on the leaders in the Premier League.
FC Barcelona look set to welcome Lionel Messi back into the mix following the Argentines recovery from injury that kept him out of action for three weeks.