After a disappointing draw at Watford on opening day, Liverpool come home to Anfield to entertain Crystal Palace - a side they don't particularly share the greatest recent record against.
Chelsea face Arsenal at Wembley in the final of the FA Cup, as they look to cap their season off with a domestic double.
Daniel Sturridge and Roberto Firmino are set to start at the expense of Divock Origi as Liverpool fight to secure Champions League football against Middlesbrough.
Jurgen Klopp could offer Daniel Sturridge a second consecutive league start for the first time this season as Roberto Firmino remains an injury doubt for Boro.
Liverpool go into the final day of the season with Champions League football on the line and nothing less than a win against relegated Middlesbrough would do for Jurgen Klopp's men.
Jose Mourinho has rung in several changes for Manchester United keeping their Europa League final in mind while Tottenham rest Kyle Walker for the final game at White Hart Lane.
Manchester United will have to do without the services of Ashley Young as they get ready to welcome Celta Vigo at Old Trafford for their second leg semi-final.
Manchester United are all set to take on Celta Vigo at home in Old Trafford for the second leg of their Europa League semi-final.
Manchester United will rest several players during their colossal Premier League clash against Arsenal.
Manchester United will travel to Celta de Vigo to play the first leg of their Europa semi-final tie after a 1-1 draw against Swansea City in the league