The Premier League Champions get their title defence underway by hosting Sean Dyche's Burnley at Stamford Bridge on Saturday
The Philip II Arena is set to host the clash of UEFA's reigning Champions as Europa League holders Manchester United take on Champions League winners Real Madrid in the Macedonian capital.
Portugal take on New Zealand in their final Group A match as they look to finish atop their group ahead of current leaders Mexico.
Before they can get their hands on the Premier League trophy, Chelsea host Championship-bound Sunderland AFC in their last League game of the season
Real Madrid travel to Galicia to face Eduardo Berizzo's Celta de Vigo, in what will be the fourth meeting between the two sides this season
League leaders Barcelona face a trip to the Canary Islands, where they will be hosted by Quique Setién's UD Las Palmas at the Estadio Gran Canaria on Sunday.
Chelsea play hosts to Steve Agnew's Middlesbrough on Monday, as they look to capitalise on Spur's defeat to move seven points clear at the summit of the League.
A big night awaits football aficionados as Manchester United will take on Arsenal in a match that is crucial to the Champions League dreams of both teams.
Zinedine Zidane and his men will be hosted by Granada CF at Los Cármenes, as they look to keep the pressure on arch rivals Barcelona at the summit of the La Liga.
Real Madrid are hit with Gareth Bale's injury as they get ready to face Deportivo La Coruna in a La Liga match after losing their El Clasico encounter 2-3.