Southampton hosts Tottenham with both sides hoping to bounce back from their difficult spell in recent games.
Manchester United continued their unbeaten league run under Ole Gunnar Solskjaer as they came from a goal down to beat Southampton 3-2 on Saturday.
A second half brace from Romelu Lukaku and an Andreas Pereira wonder-goal sealed a last-gasp 3-2 comeback win for Manchester United against Southampton.
Marcus Rashford is one of two changes made by Ole Gunnar Solskjaer as Manchester United get set to take on Southampton at Old Trafford.
Marcus Rashford is set to return to the starting lineup when Manchester United welcome Southampton to Old Trafford on Saturday afternoon.
Manchester United will be hoping to continue their unbeaten league run under Ole Gunnar Solskjaer when they host Southampton to Old Trafford.
Arsenal may have to make do without Laurent Koscielny and Ainsley Maitland-Niles when Southampton visit the Emirates on Sunday afternoon.
Arsenal are out to seek revenge over Southampton with a win and aim to keep their chase for a top-four place on-track
Out-of-favour Liverpool playmaker Adam Lallana is reportedly being linked with a return to former club Southampton in the summer transfer window.
Chelsea kicked off 2019 on a disappointing note as they were held to a drab 0-0 draw by a spirited Southampton side on Wednesday night.