Southampton will travel to the King Power stadium to take on against Leicester City, as they seek revenge after the horrific defeat in the reverse fixture.
Callum Hudson-Odoi returns to the starting lineup, while Emerson Palmieri comes in for Marcos Alonso as Chelsea get set to take on Southampton at Stamford Bridge.
Jorginho and Christian Pulisic are in line to start while Cesar Azpilicueta is a doubt for Chelsea's Premier League tie against Southampton.
Arsenal and Southampton will both be looking to arrest their respective winless streak in the Premier League as they face each other at Emirates on Saturday.
Manchester City will be hoping to keep pace with Liverpool when they welcome Southampton to the Etihad Stadium on Saturday.
Manchester City will lock horns with a struggling Southampton side in the Carabao Cup Round of 16 stages at the Etihad Stadium on Tuesday night.
Chelsea enter the international break with top four in sight, as they beat Southampton 4-1 at St. Mary's Stadium on Sunday afternoon.
Tammy Abraham and Mason Mount continued their splendid start to the season, as Chelsea cruised to a 4-1 win over Southampton on Sunday.
Callum Hudson-Odoi makes his first Premier League start of the season as Chelsea get set to take on Southampton at St. Mary's Stadium.
N'Golo Kante could be rested by Frank Lampard when Chelsea take on Southampton at St. Mary's Stadium on Sunday afternoon.