Manchester City will look to build on their sensational display against Liverpool when they face Southampton on Sunday.
Rob Holding and Kieran Tierney stood out at the back while Eddie Nketiah made the difference as Arsenal beat Southampton 2-0 on Thursday.
Granit Xhaka and Kieran Tierney return while Eddie Nketiah starts upfront as Arsenal prepare to take on Southampton at the St. Mary's Stadium.
Emiliano Martinez will replace the injured Bernd Leno while Mesut Ozil should return when Arsenal take on Southampton at St. Mary's on Thursday.
Arsenal will be desperate to get their first win since the resumption of Premier League, when they take on Southampton at St. Mary's on Thursday.
Southampton goalkeeper Fraser Forster is on the radar of Chelsea. The English international is on loan at Celtic, who is another suitor, and will likely cost 10 million.
Tottenham will be hoping to make it to the fifth round of the FA Cup when they welcome Southampton to the Tottenham Hotspur Stadium on Wednesday.
Mohamed Salah scored a brace while Alex Oxlade-Chamberlain and Jordan Henderson also found the net as Liverpool beat Southampton 4-0 on Saturday.
Liverpool midfielder Fabinho is back into the starting XI for their Premier League game against Southampton at Anfield on Saturday.
January signing Takumi Minamino could be in line to make his first Premier League start when Liverpool take on Southampton at Anfield on Saturday.