Arsene Wenger has made wholesale changes to the side that beat BATE Borisov on Thursday as Arsenal prepare to face Southampton at St. Mary's.
Manchester City will look to maintain their stranglehold atop the Premier League table when they host Southampton at the Etihad
Manchester City are reportedly set to go head-to-head with Liverpool in pursuit of Virgil van Dijk in the winter transfer window
Liverpool continued their winning run in fine fashion on Saturday as they enjoyed a comfortable 3-0 win over Southampton at Anfield.
Jurgen Klopp has made four changes to the side that thrashed West Ham United last time around, as Liverpool host Southampton at Anfield.
Liverpool will aim to continue their pre-international break winning momentum when they welcome Southampton to Anfield on Saturday.
Manchester City are reportedly eager to sign Ryan Bertrand from Southampton in January, with Benjamin Mendy sidelined with a long-term injury.
Barcelona have reportedly ramped up their interest in signing Virgil van Dijk and are set to battle Liverpool for the Southampton defender.
Romelu Lukaku and Nemanja Matic are among the nine changes made by Jose Mourinho as Manchester United prepare to take on Southampton at St. Mary's.
Jose Mourinho has no fresh injury concerns to deal with as Manchester United visit St. Mary's to take on Southampton on Saturday.