Ernesto Valverde will be without six first-team players as Barcelona travel to Estadio Municipal de Butarque to take on Leganes on Saturday.
Andres Iniesta is set to face a late fitness test to determine his availability as Barcelona host Sevilla at Camp Nou on Saturday.
Sergi Roberto, a prime target for Manchester United and Juventus, has reportedly told Barcelona that he wants to leave the club this summer.
Barcelona kicked off their campaign in La Liga on a winning note, beating Real Betis 2-0 on an emotional night for the city on Sunday night
Manchester United are reportedly considering activating Sergi Roberto's €40 million release clause to land the Spaniard this summer.
Barcelona have turned down a €40 million bid from Manchester United for Sergi Roberto, who is also a target for Chelsea.
Chelsea are reportedly keen on Barcelona star Sergi Roberto as Antonio Conte continues to scour for potential addition to the right wing-back position.
Barcelona have reportedly turned down a €35 million bid from Manchester City for Sergi Roberto, with Ernesto Valverde keen to keep the player.
The Croatian captain is set to join the Blaugranas in January on loan according to Spanish reports
The Spanish giants are said to monitoring the Italian duo, with a view of tabling a bid in the January window.