Roberto Firmino and Sadio Mane are among those who have been benched, while Divock Origi starts for Liverpool as they welcome Genk to Anfield.
Liverpool continued their perfect start to the season, with James Milner and Sadio Mane starring in their 2-1 win over Leicester City on Saturday.
Liverpool managed to fend off a spirited fightback from Red Bull Salzburg to beat them 4-3 in their second Group E fixture of the 2019-20 UEFA Champions League.
Liverpool were made to work hard for all three points against Sheffield United, with a Dean Henderson error gifting them a 1-0 win on Saturday.
Sadio Mane is fit to return to the starting lineup, as Liverpool get set to face Sheffield United at Bramall Lane on Saturday afternoon.
Goals from Sadio Mane and Roberto Firmino fired Liverpool to a victory against Southampton, despite Adrian's howler late in the game.
Liverpool trumped Southampton 2-1 at the St. Mary's Stadium on Saturday, courtesy of goals from Sadio Mane and Roberto Firmino despite a late error from Adrian.
Liverpool will look to pick up their second victory of the 2019-20 Premier League season, when they take on Southampton at St. Mary's on Saturday afternoon.
Adrian went from zero to hero as Liverpool edged out Chelsea 5-4 on penalties after a 2-2 draw post extra time to win the UEFA Super Cup.
Liverpool came from behind before edging Chelsea by the slimmest of margins, beating the Blues 5-4 on penalties to lift the UEFA Super Cup.