Maurizio Sarri will have to change his back four, with Andreas Christensen set to come in for the injured Antonio Rudiger as Chelsea take on Burnley.
We take a look at a few goalkeepers and defenders who could be key to their club's fortunes and be useful for users in the Fantasy Premier League.
Maurizio Sarri has kept the changes to a minimum as Chelsea look to get things done in their Round of 32 first leg of the UEFA Europa League against Malmo FF.
Alvaro Morata returns to the starting lineup to lead the attack for Chelsea as they face Manchester United, with Olivier Giroud dropping to the bench.
Alvaro Morata's return to form could spring him into the starting eleven as Chelsea host Manchester United in a must-win match for the visitors.
Antonio Conte has thrown another curveball benching both Olivier Giroud and Alvaro Morata for Chelsea's UEFA Champions League match against Barcelona.
Antonio Conte has reverted to a 3-5-2 formation for the match against Arsenal at Emirates, with Eden Hazard and Alvaro Morata the frontmen.
Chelsea were made to pay for their disastrous performance by a merciless and clinical AS Roma side at Stadio Olimpico on Matchday 4 of the UEFA Champions League.
Antonio Rudiger is in line to make his Premier League debut while Antonio Conte has handed Jeremie Boga a start as Chelsea face Burnley.
Manchester City are reportedly hoping to complete a £30 million summer swoop for Antonio Rudiger, beating Chelsea to the AS Roma defender.