Southampton hosts Tottenham with both sides hoping to bounce back from their difficult spell in recent games.
Manchester United will be hoping to continue their unbeaten league run under Ole Gunnar Solskjaer when they host Southampton to Old Trafford.
Arsenal are out to seek revenge over Southampton with a win and aim to keep their chase for a top-four place on-track
Chelsea will be aiming to consolidate their place in the top four when they welcome Southampton to Stamford Bridge in their first game of 2019.
Manchester City will be desperate to get back to winning ways when they travel to St. Mary's Stadium to take on Southampton on Sunday evening
Borussia Monchengladbach and RB Leipzig will look to take a major step towards reclaiming a place in the top four when they meet at Borussia Park on Saturday