Mauricio Pochettino and his Tottenham side will be looking to end a miserable run of games to begin a new chapter against a travelling Southampton side
Manchester United will be hoping to move on from their first defeat of the season when they take on Southampton at St. Mary's on Saturday.
Liverpool will look to pick up their second victory of the 2019-20 Premier League season, when they take on Southampton at St. Mary's on Saturday afternoon.
Southampton hosts Tottenham with both sides hoping to bounce back from their difficult spell in recent games.
Manchester United will be hoping to continue their unbeaten league run under Ole Gunnar Solskjaer when they host Southampton to Old Trafford.
Arsenal are out to seek revenge over Southampton with a win and aim to keep their chase for a top-four place on-track
Chelsea will be aiming to consolidate their place in the top four when they welcome Southampton to Stamford Bridge in their first game of 2019.
Manchester City will be desperate to get back to winning ways when they travel to St. Mary's Stadium to take on Southampton on Sunday evening
Borussia Monchengladbach and RB Leipzig will look to take a major step towards reclaiming a place in the top four when they meet at Borussia Park on Saturday