Two sides in terrible form will face off in search of all-important win, as safety remains the priority for Southampton and Crystal Palace.
Mikel Arteta aims to arrest Arsenal's slump as he hopes to secure three points against Southampton and get their top-four chase back on track.
Manchester United are mulling over a shock move for Southampton head coach Ralph Hasenhuttl next season.
Southampton are reportedly expected to make a £25 million offer to sign Armando Broja permanently, although much will depend on Chelsea's answer.
Southampton are keen on making the loan signing of Armando Broja permanent before the summer to ward off other interested clubs
Mohamed Elyounoussi has addressed recent transfer speculation linking him with a move to Arsenal while also reflecting on his time with Southampton.
Everton kick-start their Premier League campaign under new manager Rafael Benitez as they host Southampton at Goodison Park on Saturday.
With Mikel Arteta struggling to get results at Arsenal and his job under threat, The Hard Tackle looks at five candidates who can replace him at the Emirates.
The 2020/21 Premier League season is upon us and it's time to take a closer look at Southampton. Will the Saints continue their upward momentum under Ralph Hasenhuttl?
Mauricio Pochettino and his Tottenham side will be looking to end a miserable run of games to begin a new chapter against a travelling Southampton side