Real Madrid will look to extend their lead at the top of the table when they host Espanyol at the Santiago Bernabeu on Saturday.
Chelsea FC will come up against a Watford side fielding a traditional 4-4-2, and the Blues must deal with the combination play of forwards Odion Ighalo and Troy Deeney to get a result at Vicarage Road.
This weekend Manchester United will take on Watford and the match will see De Gea face off against the team managed by the man who gave him his big break, Quique Sanchez Flores.
With Watford set to host Arsenal FC, we take a look at the team news, tactics, lineups and predictions.
Manchester City vs Watford Review: Goals from Sterling and Fernandinho help City extend their lead at the top of the premier league table.
El Derbi Madrileno is here as Real Madrid host Atletico Madrid in what should be a fascinating contest with plenty of action.