Chelsea will look to get back to winning ways in the Premier League when they take on a Mark Hughes led Southampton side who are fighting for survival.
With the score at 3-0, Juventus will need a miracle when they take on Real Madrid in the second leg of their UEFA Champions League quarterfinal tie at the Santiago Bernabeu tonight.
FC Barcelona will play hosts to Serie A giants AS Roma at the Nou Camp in the first leg of their UEFA Champions League quarter-final tie.
In their first La Liga match after the international break, Real Madrid travel the Canary islands to face UD Las Palmas at the Estadio Gran Canaria.
Reigning champions Real Madrid host Girona FC at the Santiago Bernabeu on Sunday in match day 29 of the La Liga.
With an away goal advantage to their name, Barcelona host Chelsea at the Nou Camp in the second leg of their UEFA Champions League Round of 16 tie.
In matchday twenty eight of the La Liga, reigning champions Real Madrid face a trip to the Basque country, where they will be hosted by SD Eibar at the Ipurua Muncipal Stadium
Real Madrid will look to get back to winning ways when they host Getafe CF at the Santiago Bernabeu in matchday 27 of the La Liga.
Reigning champions Real Madrid travel to Catalonia to take on RCD Espanyol, in match day 26 of the La Liga.
Reigning champions Real Madrid resume their Champions League defence when they host Paris Saint-Germain on Wednesday in the first leg of the Round of 16.