Portugal take on New Zealand in their final Group A match as they look to finish atop their group ahead of current leaders Mexico.
Top spot in Group B will be at stake when Germany and Chile take on each other in the Confederations Cup.
Euro 2016 champions Portugal open their Confederations Cup campaign against 2015 CONCAF Cup winners Mexico.
Germany will go into their FIFA World Cup qualifier against San Marino as overwhelming favourites.
Italy and Uruguay are set to square off in an international friendly in Nice on Wednesday.
Denmark and Germany are set to go head-to-head at Brondby stadium on Tuesday night for an international friendly.
Empoli will have to fight hard for their future in the top flight as they get ready to travel to Palermo.
Borussia Dortmund and Eintracht Frankfurt are set to take on each other in the DFB-Pokal final at the Olympiastadion on Saturday.
Liverpool go into the final day of the season with Champions League football on the line and nothing less than a win against relegated Middlesbrough would do for Jurgen Klopp's men.
Real Madrid will be looking to clinch the La Liga title by getting at least a point off their trip to Malaga.