Liverpool go into the final day of the season with Champions League football on the line and nothing less than a win against relegated Middlesbrough would do for Jurgen Klopp's men.
Real Madrid will be looking to clinch the La Liga title by getting at least a point off their trip to Malaga.
Before they can get their hands on the Premier League trophy, Chelsea host Championship-bound Sunderland AFC in their last League game of the season
Real Madrid travel to Galicia to face Eduardo Berizzo's Celta de Vigo, in what will be the fourth meeting between the two sides this season
With the title now out of reach, Tottenham Hotspur will play for pride when they host Manchester United on Sunday.
Manchester United are all set to take on Celta Vigo at home in Old Trafford for the second leg of their Europa League semi-final.
Atletico Madrid will have a mountain to climb as they hope to recover a three-goal deficit over Real Madrid on Wednesday.
Chelsea play hosts to Steve Agnew's Middlesbrough on Monday, as they look to capitalise on Spur's defeat to move seven points clear at the summit of the League.
Liverpool will be looking to regain third spot when they host Southampton on Sunday.
A big night awaits football aficionados as Manchester United will take on Arsenal in a match that is crucial to the Champions League dreams of both teams.