Antonio Conte will hope to get his side back to winning ways as they travel to the West Midlands today to face Wolverhampton Wanderers in the Fifth Round of the FA Cup.
Real Madrid host Napoli in the first leg of the UEFA Champions League Round of 16 match on Wednesday.
Burnley are set to host league leaders Chelsea at Turf Moor as they look to become the first side to inflict defeat the on Blues since Tottenham in January.
If they are to keep themselves alive in the title race, Barcelona will have to get past an Athletic Bilbao side seeking revenge for their exit from the Copa Del Rey last month.
Everything you need to know before Liverpool take on Middlesbrough on Wednesday night
Barcelona travel to Osasuna on Saturday night as La Liga action resumes.
Arsenal travel to Switzerland for their final UEFA Champions League Group Stage fixture against FC Basel.
Antonio Conte's Chelsea face their biggest test this season in the former of Pep Guardiola's Manchester City, who are looking to leapfrog the Blues into first place with a victory.
We preview Friday night's key Serie A clash between Napoli and Inter Milan
Arsene Wenger is likely to field some academy graduates as Arsenal face Southampton in EFL Cup tie.