Bragging rights will be at stake when two cross-town rivals Manchester United and Manchester City go head-to-head in a grueling EFL Cup tie.
Arsenal will be looking continue their winning run when the visit the Turf Moor to take on a resolute Burnley side
Manchester United will be looking to continue their two-game winning run when they play host to Ukrainian side Zorya Luhansk in the Europa League on Thursday.
The odds are in Tottenham's favour as they look to overcome Alan Pardew's troubled Crystal Palace at White Hart Lane on Saturday.
Tactically astute Italy are set to take on unbeaten Germany in a fiesty quarter-final encounter of the Euro 2016 at Bordeaux.
USA take on Ecuador in the the first quarterfinal of the Copa America Centenario as Jurgen Klinsmann's men look to make full use of their home advantage in their bid to qualify for the semi-finals.
Arsenal host a Championship bound Aston Villa side at the Emirates, as the Gunners look to end a disappointing season on a positive note.
Sunderland host Chelsea at the Stadium Of Light on Saturday as they look for a valuable victory to help keep them alive in the Premier League for next season.
Real Madrid host Manchester City in the second leg of the UEFA Champions League Semi-final at the Santiago Bernabeu.
Atletico Madrid face Bayern Munich in the first leg of the semi finals of the UEFA Champions League at the Vicente Calderon in a clash of contrasting philosophies between Diego Simeone and Pep Guardiola.