Barcelona travel to Osasuna on Saturday night as La Liga action resumes.
Arsenal travel to Switzerland for their final UEFA Champions League Group Stage fixture against FC Basel.
Antonio Conte's Chelsea face their biggest test this season in the former of Pep Guardiola's Manchester City, who are looking to leapfrog the Blues into first place with a victory.
We preview Friday night's key Serie A clash between Napoli and Inter Milan
Arsene Wenger is likely to field some academy graduates as Arsenal face Southampton in EFL Cup tie.
Arsenal host Bournemouth at the Emirates on Sunday in a bid to continue their run of 18 games without defeat and stay within touching distance of league leaders Chelsea.
Arsenal host Bournemouth at The Emirates on Sunday afternoon, with Jack Wilshere set to watch on from the sidelines
League leaders Chelsea welcome fierce rivals Tottenham Hotspur who are looking to get back to winning ways after being knocked out of the Champions League by Monaco.
Chile and Colombia face each other in what is one of the most important fixtures in the CONMEBOL world cup qualifiers on Thursday evening.
Jorge Sampaoli's high flying Sevilla will welcome a wounded Barcelona side who will look to try and get back to winning ways against a side that is yet to be defeated at home this season.