Defending champions Chelsea welcome Watford to Stamford Bridge on Saturday, as they look for their first victory in all competitions since September.
Defending champions Real Madrid play hosts to RCD Espanyol on Sunday, as they continue to try and claw themselves back to the top of the summit of the La Liga.
Atletico Madrid take on Premier League champions Chelsea, in what will be the first ever UEFA Champions League match at their new Wanda Metropolitano Stadium.
APOEL Nicosia host Tottenham at the GSP Stadium, for what will be the first ever meeting between the two sides in the UEFA Champions League.
Defending Champions Chelsea head to the King Power Stadium, where they will face Craig Shakespeare's Leicester City in the first of their seven games this month.
The iconic Wembley Stadium is set to host the first London derby of the season on Sunday, when defending champions Chelsea take on arch rivals Tottenham Hotspur
The Premier League Champions get their title defence underway by hosting Sean Dyche's Burnley at Stamford Bridge on Saturday
The Philip II Arena is set to host the clash of UEFA's reigning Champions as Europa League holders Manchester United take on Champions League winners Real Madrid in the Macedonian capital.
Mexico will have to face-off against a young German side in an intense semi-final match as both teams look to add more to their already glittering trophy cabinets.
Portugal take on New Zealand in their final Group A match as they look to finish atop their group ahead of current leaders Mexico.