Anthony Martial and Luke Shaw come into the Manchester United starting eleven as a tough test await the Red Devils at Manchester City.
Manchester United will be looking to close down the gap between them and the top four as they face a daunting task against Manchester City at Etihad.
Chelsea will be looking to bounce back from their back-to-back losses in the Premier League when they host Aston Villa at Stamford Bridge on Wednesday.
Manchester United will be looking to return to winning ways when they host Aston Villa at Old Trafford in the Premier League on Sunday.
Chelsea will look to strengthen their top four credentials as they face West Ham United at Stamford Bridge on Saturday in a London derby.
Tottenham Hotspur will be looking to make it three wins in three under new boss Jose Mourinho, when they take on AFC Bournemouth on Saturday.
Manchester City will be hoping to close down the gap to the top of the table when they go head to head against with Newcastle United away from home this weekend.
Unai Emery confirmed that Nicolas Pepe is available to be picked on Saturday despite arriving late from international duty as Arsenal face Southampton.
Virgil van Dijk withdrew from Netherlands duty due to personal reasons, but is available for Liverpool as they take on Crystal Palace on Saturday.
Arsenal and Southampton will both be looking to arrest their respective winless streak in the Premier League as they face each other at Emirates on Saturday.