Antonio Conte will hope to get his side back to winning ways as they travel to the West Midlands today to face Wolverhampton Wanderers in the Fifth Round of the FA Cup.
Burnley are set to host league leaders Chelsea at Turf Moor as they look to become the first side to inflict defeat the on Blues since Tottenham in January.
If they are to keep themselves alive in the title race, Barcelona will have to get past an Athletic Bilbao side seeking revenge for their exit from the Copa Del Rey last month.
Chelsea welcome League One side Peterborough United to Stamford Bridge for their third round FA Cup tie.
Barcelona welcome an in-form Espanyol side to Nou Camp for what promises to be an exciting Catalan Derby, as they look to end the calendar year with their first home Liga victory since October.
League leaders Chelsea welcome fierce rivals Tottenham Hotspur who are looking to get back to winning ways after being knocked out of the Champions League by Monaco.
Sunderland host Chelsea at the Stadium Of Light on Saturday as they look for a valuable victory to help keep them alive in the Premier League for next season.
Real Madrid host Manchester City in the second leg of the UEFA Champions League Semi-final at the Santiago Bernabeu.
Southampton host Champions League semifinalists Manchester City on Sunday hoping to gain maximum points and get closer to securing a Europa League spot.
Looking to maintain his 100% win record since taking over the reins from Rafael Benitez, Zinedine Zidane and his team travel to Real Betis in a bid to keep up Barcelona and Atletico Madrid in the Spanish La Liga.