Antonio Conte's Chelsea face their biggest test this season in the former of Pep Guardiola's Manchester City, who are looking to leapfrog the Blues into first place with a victory.
Arsenal host Bournemouth at The Emirates on Sunday afternoon, with Jack Wilshere set to watch on from the sidelines
Chile and Colombia face each other in what is one of the most important fixtures in the CONMEBOL world cup qualifiers on Thursday evening.
Jorge Sampaoli's high flying Sevilla will welcome a wounded Barcelona side who will look to try and get back to winning ways against a side that is yet to be defeated at home this season.
Arsenal host a Championship bound Aston Villa side at the Emirates, as the Gunners look to end a disappointing season on a positive note.
Germany play host to Italy on Tuesday, 29th of March at the Allianz-Arena in Munich in a much anticipated high profile friendly match ahead of Euro 2016. Having run into a terrible run of form recently, the Germans are still licking their wounds from Saturday's 3-2 defeat to England. Italy on the other hand, are coming off the back of an impressive display against Spain at home where they kept La Furia Roja at bay with a 1-1 draw.
The second leg of the round of 16 Europa League tie between Tottenham Hotspur and Borussia Dortmund promises to be an exciting clash, with the German side in a commanding position after a 3-0 home win in the first leg last week.
Manchester City host Dynamo Kiev as they look to reach the quarter-finals of the Champions League for the first time in their history. A two-goal advantage ensures that the Citizens go into the fixture as the firm favourites against the Ukrainian outfit.
Real Madrid host 15th placed Las Palmas as Zinedine Zidane looks to keep their momentum going following a 2-0 win over AS Roma in the second leg of the round of 16 Champions League tie.
With one foot already in the quarter-finals, Real Madrid host AS Roma in the second leg of the Champions League round of 16 tie.