Portugal will aim to avoid defeat as they look to finish as group winners when they host Serbia in a top of the table clash this weekend.
Portugal are gunning for the top spot in Group A, which they could achieve with a win over a beleaguered and already eliminated Republic of Ireland side.
Portugal will be aiming to move to the top of Group A in the FIFA World Cup 2022 Qualifiers when they take on Luxembourg at Estadio Algarve on Tuesday night.
Cristiano Ronaldo scored again as Portugal secured a comfortable 3-0 victory in an international friendly against Qatar on Saturday.
Portugal kickstart their international window on Saturday as they welcome World Cup 2022 hosts Qatar in Alguacil.
Joao Cancelo and Bruno Fernandes were in stunning form as Portugal cruised to a 3-0 win over Azerbaijan on Tuesday.
Portugal will be aiming to end the international break with a third successive win when they face Azerbaijan in Baku on Tuesday.
Goncalo Guedes and Joao Mario impressed as Portugal sealed a comfortable 3-1 victory over Qatar on Saturday.
Portugal travel to the Nagyerdei Stadion in Debrecen on Saturday as they lock horns with Qatar in an international friendly on Saturday.
Cristiano Ronaldo made history with two late goals as Portugal snatched three points off Republic of Ireland with a 2-1 win on Wednesday.