The champions of Europe came back from a goal down to complete a stunning 3-1 victory against Paris Saint-Germain at the Santiago Bernabeu
The Blues cruised to an comfortable victory at Stamford Bridge with goals from Eden Hazard and Victor Moses proving enough to secure all three points.
The reigning champions were put to the sword by Eddie Howe's fearless Bournemouth side, after a second half masterclass at Stamford Bridge.
A late Lionel Messi freekick helped secure all three points for Barcelona against a resilient Deportivo Alaves side at the Nou Camp.
Cristiano Ronaldo got a brace as Real Madrid cruised to an easy victory against Valencia at the Mestalla Stadium.
Gareth Bale, Cristiano Ronaldo and Nacho Hernandez all netted twice against a helpless Deportivo side in the champions' biggest victory La Liga of the season.
A wasteful Real Madrid were put to the sword by Villarreal, after Pablo Fornal's late goal ensured that the champions succumbed to their fourth Liga defeat of the season
Manchester United played a goalless stalemate at Old Trafford against a resurgent Southampton side on Saturday evening to drop down to 3rd on the table.
Luis Suarez and Lionel Messi helped Barcelona secure all three points at the Estadio de la Ceramica against a tough Villarreal CF side.
Reigning champions Chelsea succumbed to a narrow, frustrating loss to cross town rivals West Ham United at the London Stadium on Saturday.