Pep Guardiola will look for an immediate response from his team against Crystal Palace, who will be hoping to do the double over Manchester City.
Tottenham and Manchester City clash Tuesday night in the UEFA Champions League quarter-final first leg, in what is the sixth all English Last Eight tie.
Manchester City take on Brighton & Hove Albion in the FA Cup semi-finals, aiming to take a significant step towards the unprecedented quadruple.
Manchester City could reclaim top spot at least temporarily with a win over relegation-threatened Cardiff City
Manchester City travel to London with a chance to reclaim top spot in the Premier League, while relegation looms large for Fulham.
Manchester City will be aiming to keep their hopes of a quadruple burning bright, when they take on German outfit Schalke 04 in the UEFA Champions League.
Manchester City take on Watford knowing they can put further pressure on second-placed Liverpool by opening up a four-point lead at the top of the table.
Manchester City will be hoping to keep up the pressure on Premier League leaders Liverpool, when they take on AFC Bournemouth on Saturday.
Manchester City will look to maintain pressure on league leaders Liverpool as they host West Ham United at the Etihad on Wednesday
The first major trophy of the English season will be up for grabs on Sunday when Chelsea take on Manchester City in the Carabao Cup final at Wembley.