Barcelona will be without key men Gerard Pique, Luis Suarez and Lionel Messi for their trip to Estadio El Alcoraz, where they face off against Huesca.
Ousmane Dembele is available for selection, but is unlikely to be handed a start when Barcelona face off against Manchester United in the UEFA Champions League.
Ousmane Dembele will miss out for Barcelona when they lock horns with Real Betis at Estadio Benito Villamarin on Sunday night.
Ousmane Dembele's availability is in doubt ahead of Barcelona's Round of 16 second leg in the UEFA Champions League against Lyon on Wednesday.
Ernesto Valverde is without just two first-team players ahead of Barcelona's Copa del Rey semi-final second leg against Real Madrid on Wednesday.
Ousmane Dembele and Carles Alena are expected to return to the starting lineup when Barcelona welcome Real Valladolid to Camp Nou on Saturday.
The suspended Jordi Alba will be one of five first-team players unavailable when Barcelona pay a visit to San Mames to face Athletic Bilbao on Sunday.
Barcelona were made to work hard for all three points by a spirited Leganes side, with Ousmane Dembele inspiring a 3-1 win at Camp Nou on Sunday.
Barcelona completed the turnaround in their Round of 16 tie against Levante in stunning fashion, coasting to a 3-0 win at Camp Nou on Thursday.
Defending champions Barcelona will finish 2018 as the La Liga leaders after they eased past Celta Vigo in a 2-0 win at Camp Nou on Saturday evening.