USA and Uruguay will face off against each other for the first time in over seventeen years, in an international friendly in St. Louis, Missouri.
A place in the Copa America semi-finals will be on the line when Uruguay take on Peru at Itaipava Arena Fonte Nova on Saturday.
Two of the tournament favourites will clash in Rio de Janeiro on Monday night, as Chile take on Uruguay in their final 2019 Copa America Group C encounter.
Uruguay will be hoping to book their place in the quarter-finals of the 2019 Copa America when they take on Japan at Arena do Gremio.
The first fixture of the Group C of the 2019 Copa America will see Uruguay take on Ecuador at the Estadio Governador Magalhães Pinto on Sunday night.
France and Uruguay are set to lock horns in what will be a replay of the 2018 FIFA World Cup quarter-final clash at Stade de France on Tuesday.
Two South American heavyweights clash against each other on Friday night as Brazil face off against Uruguay at the Emirates Stadium, London.
France and Uruguay will go head to head against each other in the first quarterfinal of the 2018 FIFA World Cup in Russia on Friday.
A place in the quarter-finals will be up for grabs when Uruguay and Portugal meet at the Fisht Olympic Stadium in their Round of 16 match on Saturday.
Egypt and Uruguay will look to kick off their World Cup campaign with a win when they meet at Krestovsky Stadium in Saint Petersburg on Friday