Arsenal slumped to a third consecutive defeat as their top-four hopes suffered another blow, with Southampton securing a narrow victory.
Alexandre Lacazette is missing from the squad, with Eddie Nketiah leading the line for Arsenal against Southampton, while Nuno Tavares plays left-back.
Albert Sambi Lokonga is likely to start in place of Thomas Partey, while Gabriel Martinelli could come in for Emile Smith Rowe against Brighton.
Mikel Arteta will seek to get the top-four hunt back on track when Arsenal welcome a struggling Brighton & Hove Albion to the Emirates on Saturday.
Serie A giants Lazio are reportedly plotting a January loan move for Arsenal defender Nuno Tavares, who is yet to cement his place at the Emirates.
Charlie Patino will start again, while Kieran Tierney will replace Nuno Tavares when Arsenal and Liverpool face off at Anfield on Thursday.
Nottingham Forest condemned Arsenal to a shock defeat to knock them out of the FA Cup, as Mikel Arteta's men were victims of their sloppiness
Arsenal booked their place in the semi-finals of the EFL Cup after smashing five goals past League One side Sunderland at the Emirates.
Manchester City are reportedly interested in Arsenal's Nuno Tavares, who only moved to the Premier League in the summer
Gabriel Agbonlahor has claimed Nuno Travares offers more on the pitch to Arsenal than teammate and fellow left-back Kieran Tierney.
