Nicolas Pepe comes into the side for Gabriel Martinelli, while Dani Ceballos returns to the starting lineup as Arsenal get set to take on Newcastle United.
David Luiz and Pierre-Emerick Aubameyang return while Nicolas Pepe has been benched as Arsenal get set to take on Burnley at Turf Moor.
Nicolas Pepe was the clear standout for Arsenal, as they were held to a 1-1 draw by Sheffield United after Gabriel Martinelli's strike was cancelled out by John Fleck.
Arsenal will be hoping to continue building a winning momentum when they take on Crystal Palace at Selhurst Park on Saturday.
Arsenal boss Mikel Arteta has made four changes to the side that started against Chelsea this past weekend for the home game against Manchester United.
Nicolas Pepe is fit to start while Alexandre Lacazette is set to be benched when Arsenal welcome Manchester City to the Emirates on Sunday.
Nicolas Pepe is expected to make his first start under Freddie Ljungberg as Arsenal look to end their winless run at the Emirates against Brighton on Thursday.
Nicolas Pepe is set to return to the starting lineup when Arsenal pay Norwich City a visit at Carrow Road on Sunday.
Arsenal manager Unai Emery has opted for a three-man backline for his side's UEFA Europa League contest against Vitoria SC on Wednesday evening.
Arsenal manager Unai Emery is expected to make wholesale changes to the starting XI when his team take on Vitoria SC in the UEFA Europa League.