The final Manchester derby of the season sees both sides of Manchester in dire straits, as they struggle to get their Premier League campaign back on track with time running out.
Manchester United and Liverpool have both been charged by UEFA following crowd trouble at their Europa League clash at Old Trafford, the governing body announced on Friday.
Brazilian playmaker Philippe Coutinho's stylish goal earned Liverpool a 1-1 draw at Manchester United on Thursday as Jurgen Klopp's men eliminated their arch foes from the Europa League.
Although the duo of Ashley Young and Cameron Borthwick-Jackson have returned to training, they are unlikely to be fit enough to start against Liverpool. The same goes for Bastian Schweinsteiger, even though the German made his comeback against West Ham in the FA Cup.
Liverpool welcome back veteran England midfielder James Milner, who missed the first leg of their Europa League round of 16 clash against Manchester United because of an illness.
Manchester United's purple patch has faded just as abruptly as it started, with the Red Devils losing to Liverpool in the Europa League following a Premier League defeat to West Bromwich Albion.