Arsene Wenger will be boosted by the return of Petr Cech and Laurent Koscielny who are both in line to return to action as Middlesbrough host Arsenal.
Arsenal will be looking to pick up 3 points against Middlesbrough at the Riverside, since Agnew's men have not a won a single game in 2017 so far.
Manchester United came away with a battling 3-1 win over Middlesbrough at the Riverside Stadium but there were questions raised on the approach adopted.
Jose Mourinho will be without Zlatan Ibrahimovic and Paul Pogba as Manchester United travel to face a manager-less Middlesbrough in the Premier League.
Manchester United travel to the Riverside Stadium to battle a manager-less Middlesbrough, with a chance to move to 5th on the Premier League table.
Arsenal have joined Chelsea and Manchester City in the the race for Middlesbrough defender Ben Gibson according to reports
Manchester City are reportedly interested in Middlesbrough defender Ben Gibson and are set to compete with Chelsea in summer pursuit of the Englishman.
Liverpool are reportedly lining up a shock summer swoop for Middlesbrough Gaston Ramirez, who was linked to Leicester City in January
Chelsea have shown in recent years that they don't mind selling promising young players, and the latest one to leave Stamford Bridge is 23-year-old English striker Patrick Bamford.
Chelsea have approached fellow Premier League side Middlesbrough over the availability of winger Adama Traore.