Emiliano Martinez will replace the injured Bernd Leno while Mesut Ozil should return when Arsenal take on Southampton at St. Mary's on Thursday.
Hector Bellerin is expected to start while Nicolas Pepe and Mesut Ozil are in line to return to the lineup when Arsenal play Everton in the Premier League.
Nicolas Pepe was the game changer for Arsenal as they beat Newcastle United 4-0 to record their seventh Premier League win of the season on Sunday.
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Rob Holding returns to the starting lineup as part of a back three while Mesut Ozil starts again as Arsenal get set to take on Leeds United in the FA Cup third round.
Alexandre Lacazette returns to the starting lineup while Mesut Ozil replaces Emile Smith Rowe as Arsenal get set to take on Bournemouth at Dean Court.
A Kevin De Bruyne masterclass condemned Arsenal to an embarrassing 3-0 defeat at the hands of Manchester City at home on Sunday evening.
Nicolas Pepe is expected to make his first start under Freddie Ljungberg as Arsenal look to end their winless run at the Emirates against Brighton on Thursday.
Freddie Ljungberg will be desperate to register his first win as Arsenal manager when the Gunners plays hosts to Brighton & Hove Albion on Thursday.