Arsene Wenger will be without Granit Xhaka but will be buoyed by the availability of most of his players, including Danny Welbeck as Arsenal face Watford.
Jose Mourinho will look to avoid a third successive defeat as Manchester United face a tricky away fixture against Watford.
Watford are reportedly in talks to bring Chelsea's young Brazilian Kenedy on a season-long loan.
Walter Mazzarri will need to steady an Inter ship which has been tumbling in choppy waters recently. How will the Nerazzuri shape under the former Napoli coach?