Top four hopefuls Tottenham take on already relegated Huddersfield in only the second home league game at their new stadium, hoping to keep the winning run going.
Tottenham and Manchester City clash Tuesday night in the UEFA Champions League quarter-final first leg, in what is the sixth all English Last Eight tie.
Tottenham Hotspur will be playing their first-ever match in their new stadium as they host Crystal Palace at the Tottenham Hotspur Arena on Wednesday
Former Manchester United superstar Dimitar Berbatov has urged Mauricio Pochettino to emulate Sir Alex Ferguson at Tottenham.
Liverpool will be hoping to return to the top of the Premier League table when they host Tottenham Hotspur at Anfield in a crucial encounter for both sides.
Southampton hosts Tottenham with both sides hoping to bounce back from their difficult spell in recent games.
Borussia Dortmund will have it all to do in their UEFA Champions League Round of 16 second leg when they host Tottenham Hotspur at Signal Iduna Park.
A wounded Chelsea side will welcome London rivals Tottenham Hotspur to Stamford Bridge on Wednesday, as they look to close the gap to the fourth place.
Tottenham Hotspur travel to Turf Moor this weekend, to face a tricky Burnley side as Mauricio Pochettino's men look to close the gap at the top of the table.
Tottenham will clash against German league leaders Borussia Dortmund for the first leg of their UEFA Champions League Round of 16 tie on Wednesday night.