Jorginho comes into the starting lineup in place of Mateo Kovacic while Christian Pulisic returns as Chelsea get set to take on Brighton at the Amex Stadium.
Mateo Kovacic will be back after serving his one match ban, while Mason Mount and Christian Pulisic are in line to start when Chelsea face Arsenal on Sunday.
Chelsea manager Frank Lampard has recalled Mason Mount to the starting XI in place of Mateo Kovacic for his team's Premier League clash against Bournemouth.
Chelsea leapt up to third on the Premier League table as they narrowly edged rock-bottom Watford 2-1 at Vicarage Road on Saturday.
Mateo Kovacic will replace the injured Ross Barkley when Chelsea face off against Ajax in their third UEFA Champions League Group H fixture.
N'Golo Kante could be rested by Frank Lampard when Chelsea take on Southampton at St. Mary's Stadium on Sunday afternoon.
Chelsea midfielder Mateo Kovacic has explained the difference between Maurizio Sarri and Frank Lampard, pointing towards the freedom he is enjoying under his new boss.
Chelsea have confirmed their first signing of the summer transfer window, with Mateo Kovacic joining from Real Madrid on a five-year deal.
Chelsea continued the defence of their FA Cup crown with a comfortable 3-0 win over Sheffield Wednesday at Stamford Bridge in the fourth round on Sunday.
Maurizio Sarri has an injury crisis on his hands ahead of Chelsea's first game of 2019, as Southampton pay them a visit at Stamford Bridge on Wednesday.