Anthony Martial is a major doubt, but Bruno Fernandes and Marcus Rashford will return when Manchester United face Brighton & Hove Albion on Sunday.
Eric Bailly's valiant defending saw Manchester United pocket all three points in a 2-1 win over Aston Villa in the Premier League on Friday Night.
Manchester United will have to be wary of West Ham's form as they travel to face the high-flying Hammers in the Premier League on Saturday.
Manchester United were made to rue for missing clear chances as PSG earned a hard-fought 3-1 win to throw Group H of the UEFA Champions League wide open.
Ole Gunnar Solskjaer will likely retain Axel Tuanzebe and Alex Telles from the PSG win as Manchester United take on RB Leipzig in the UEFA Champions League.
Manchester United will be looking to get an early lead in Group H of the UEFA Champions League as they meet fellow Matchday 1 winners RB Leipzig on Wednesday.
The 2018 World Cup finalists go head-to-head in the group stages of the UEFA Nations League at the Stade de France on Tuesday.
Anthony Martial and Paul Pogba will have to suffice with a place on the bench as Manchester United take on Chelsea in the FA Cup semi-final.
Manchester United will look to take a big step towards reaching the Last 16 stages of the UEFA Europa League when they take on Club Brugge on Thursday.
Anthony Martial and Luke Shaw come into the Manchester United starting eleven as a tough test await the Red Devils at Manchester City.