A ten-man Real Madrid side were beaten 1-2 by relegation battlers Girona at the Santiago Bernabeu on Sunday afternoon.
Gareth Bale is unlikely to be afforded a place in the starting eleven for Real Madrid as they prepare for the Madrid derby away at Atletico Madrid.
Real Madrid suffered their biggest home defeat in Europe as CSKA Moscow beat the UEFA Champions League holders at the Bernabeu on Wednesday
Santiago Solari will oversee his first match as the permanent Real Madrid manager, with just three players unavailable to face SD Eibar on Saturday.
Santiago Solari is without five first-team players as Real Madrid prepare to welcome Real Valladolid to the Santiago Bernabeu on Saturday evening.
Real Madrid are reportedly facing the risk of losing star defender Marcelo in January, with the Brazilian keen on joining Juventus
Real Madrid's travails continued on Saturday as they were condemned to a 2-1 defeat at the hands of Levante at Santiago Bernabeu.
The pressure is growing on Julen Lopetegui as Real Madrid plunged to their third defeat in a row, albeit only narrowly so as Levante recorded a 2-1 win at the Bernabeu.
Isco and Marcelo are set to start, while Gareth Bale is in contention to play as Real Madrid prepare to host Levante to Santiago Bernabeu on Saturday.
Real Madrid might have a defensive crisis at hand, with both their first-choice full-backs doubtful for the clash against Atletico Madrid.