Barcelona are set to be without Luis Suarez, who should be replaced by Malcom when they take on Getafe at Camp Nou on Sunday.
Barcelona were unceremoniously dumped out of the Champions League, as Liverpool beat them 4-0 on Tuesday night overturning a three-goal first leg deficit.
Ernesto Valverde will make wholesale changes to his Barcelona side that lost to Celta Vigo, for their UEFA Champions League semi-final second leg against Liverpool.
Barcelona will be aiming to qualify for their first UEFA Champions League final under Ernesto Valverde, when they travel to Anfield to take on Liverpool.
Lionel Messi and Luis Suarez are among a host of players that are set to return to the starting lineup when Barcelona host Manchester United at Camp Nou.
Barcelona inched closer to successfully retaining their La Liga crown when they beat Atletico Madrid 2-0 at Camp Nou on Saturday night.
Barcelona had to work hard for all three points against a resilient 10-man Atletico Madrid as late goals from Lionel Messi and Luis Suarez earned them all three points.
Lionel Messi and Luis Suarez are fit to start as Barcelona prepare to host Espanyol at Camp Nou in the second Derby Barceloni of the season.
Barcelona reached the Copa del Rey final on Wednesday, handing a 3-0 loss to Real Madrid in the semi-final second leg at the Santiago Bernabeu.
Barcelona will be aiming to stretch their lead at the top of the La Liga table, when they face off against Sevilla at the Ramon Sanchez Pizjuan on Saturday.