With an unfavourable 1-1 scoreline, Antonio Conte's men face Barcelona at the Nou Camp in the second leg of the UEFA Champions League Round of sixteen clash.
Defending Champions Chelsea head to the King Power Stadium, where they will face Craig Shakespeare's Leicester City in the first of their seven games this month.
The Premier League Champions get their title defence underway by hosting Sean Dyche's Burnley at Stamford Bridge on Saturday
The Philip II Arena is set to host the clash of UEFA's reigning Champions as Europa League holders Manchester United take on Champions League winners Real Madrid in the Macedonian capital.
Jose Mourinho has picked Chris Smalling and Juan Mata to start in the crucial Europa League final against Ajax.
Chelsea will remain mostly unchanged as they get ready to lift the coveted Premier League trophy after their final game of this season.
Jose Mourinho has named a number of youngsters in his matchday squad against Crystal Palace
Real Madrid travel to Galicia to face Eduardo Berizzo's Celta de Vigo, in what will be the fourth meeting between the two sides this season
After going off against Watford on Monday, many feared that Philippe Coutinho's injury was serious. However, the Brazilian has fought it off, and is now named in the starting eleven for Liverpool's home game against Southampton.
Zinedine Zidane and his men will be hosted by Granada CF at Los Cármenes, as they look to keep the pressure on arch rivals Barcelona at the summit of the La Liga.