Pep Guardiola will look for an immediate response from his team against Crystal Palace, who will be hoping to do the double over Manchester City.
Manchester City host Arsenal in a crucial fixture that is significant in the title race as well as the top four, as both sides look to collect three points.
Manchester City takes on Hoffenheim in their final group stage game with the visitors needing a point to finish their group as toppers
Manchester City play hosts to fellow Premier League outfit Fulham in the fourth round of the Carabao Cup on Thursday night.
Manchester City travel to Wales to face newly promoted Cardiff City as they look to the response after their Champions League disappointment.
Leroy Sane has tipped Chelsea to be the biggest challengers to Manchester City for the Premier League title in the 2018-19 season
Leroy Sane is the latest Manchester City player to be linked with a summer move, with Real Madrid reportedly plotting an €80 million summer move for the German.
Manchester City salvaged a 2-2 draw against Middlesbrough, thanks to a late equaliser in a thrilling match at the Riverside.
Arsene Wenger's reaction said it all at full time, after Arsenal defeated Manchester City 2-1 and sailed into the finals of the FA Cup.
Manchester City recorded an impressive 3-0 victory over Southampton at St Mary's stadium, a result that temporarily catapulted them to third on the Premier League table before Liverpool's win brought them back down to 4th.