Zlatan Ibrahimovic and Ander Herrera return to the starting lineup for Manchester United as Jose Mourinho looks to secure a win over Everton at Old Trafford.
Pep Guardiola takes his Manchester City side to Goodison to face an Everton side, who look formidable under the tutelage of Ronald Koeman.
Everton host Liverpool at Goodison Park as Merseyside stands divided in their first derby of the 2015-16 Premier League campaign.
Southampton have reportedly set an asking price of £15m for Jose Fonte, who is a January target for Manchester United.
Everton host an in-form Arsenal on Tuesday as Ronald Koeman hopes for his team to recapture their early season form.
Manchester United welcome Paul Pogba back from suspension but will be without captain and former Evertonian Wayne Rooney.
Manchester United travel to Goodison Park to face a struggling Everton in a Sunday fixture in the Premier League.
Barcelona have now emerged as new favourites, over Everton, in the race to sign young Ajax superstar Davinson Sanchez.
Everton are preparing a January loan bid to rival AS Roma for the signature of beleaguered Manchester United winger Memphis Depay.
Manchester City were held on to a draw by Ronald Koeman's men at the Etihad Stadium thanks to Maarten Stekelenburg's heroics between the sticks