The Philip II Arena is set to host the clash of UEFA's reigning Champions as Europa League holders Manchester United take on Champions League winners Real Madrid in the Macedonian capital.
League leaders Barcelona face a trip to the Canary Islands, where they will be hosted by Quique Setién's UD Las Palmas at the Estadio Gran Canaria on Sunday.
A big night awaits football aficionados as Manchester United will take on Arsenal in a match that is crucial to the Champions League dreams of both teams.
We preview Friday night's key Serie A clash between Napoli and Inter Milan
Arsenal host Bournemouth at The Emirates on Sunday afternoon, with Jack Wilshere set to watch on from the sidelines
Chile and Colombia face each other in what is one of the most important fixtures in the CONMEBOL world cup qualifiers on Thursday evening.
The second leg of the round of 16 Europa League tie between Tottenham Hotspur and Borussia Dortmund promises to be an exciting clash, with the German side in a commanding position after a 3-0 home win in the first leg last week.