Arsenal await another away test as they travel to Watford in pursuit of a top-four place and their first Premier League clean sheet away from home this season.
Ole Gunnar Solskjaer will be aiming to kickstart his spell as the permanent Manchester United manager with a win against Watford on Saturday.
Manchester City take on Watford knowing they can put further pressure on second-placed Liverpool by opening up a four-point lead at the top of the table.
Title aspirants Liverpool will look to bounce back to winning form as they host Watford at Anfield on Wednesday
Tottenham host Watford in the Premier League with Mauricio Pochettino's men looking to put the cup disappointments behind them and get back into their rhythm.
Liverpool will go head to head against Watford on Saturday, as the Premier League returns to action after the two-week international break.
Arsenal are set to host Watford, as Unai Emery eyes a win over the Hornets to leapfrog them into the fourth position on the Premier League table
With the international break coming to an end, Manchester United return to Premier League action this Saturday, with a trip to Vicarage Road to take on Watford.
Tottenham Hotspur will look to build on their confidence boosting win over Manchester United when they face Watford at Vicarage Road on Sunday
Manchester United will welcome Watford to the Old Trafford for their final Premier League fixture of the 2017/18 season on Sunday.