Six players, including Jadon Sancho and Harry Maguire, have been ruled out as Manchester United get set to face Chelsea in the Premier League.
Raphael Varane replaces Harry Maguire in defence, while Cristiano Ronaldo, Scott McTominay and Jadon Sancho start for Manchester United against Arsenal.
Manchester City thrashed neighbours Manchester United 4-1 in the Premier League at the Etihad on Sunday with Kevin De Bruyne stealing the show.
Roy Keane has backed Manchester United to clinch a top-four finish in the Premier League while praising Jadon Sancho for his recent form.
Jadon Sancho and Paul Pogba stood out, but Cristiano Ronaldo was sub-par as Southampton held Manchester United to a 1-1 draw on Saturday.
Paul Pogba and Jadon Sancho impressed, but Harry Maguire was poor as Manchester United were held to a frustrating 1-1 draw by Burnley in the Premier League.
Paul Pogba was impressive on return, but Cristiano Ronaldo was sub-par as Manchester United got ousted from the FA Cup by Middlesbrough on Friday.
Manchester United will be desperate to return to winning ways when they take on Brentford at the Brentford Community Stadium on Wednesday.
Scott McTominay was the star of the show while Cristiano Ronaldo scored and assisted a goal apiece as Manchester United beat Burnley 3-1 in the Premier League.
Donny van de Beek and Jadon Sancho should start while Bruno Fernandes will miss out when Manchester United take on Burnley in the Premier League.