Top four hopefuls Tottenham take on already relegated Huddersfield in only the second home league game at their new stadium, hoping to keep the winning run going.
Goals from Alex Iwobi and Alexandre Lacazette helped Arsenal to their first away win this year, as they beat Huddersfield Town 1-2 at the John Smith's Stadium.
Denis Suarez will have to be patient for his first league start as an Arsenal player, with the star named on the bench for the match against Huddersfield.
Unai Emery is having to deal with even more injuries in defence, as Arsenal travel to Huddersfield and look to bounce back after their loss to Manchester City to get back in the race for the top four.
Arsenal will look to bounce back from their defeat to Manchester City with a win over bottom side Huddersfield and pull themselves back into the race for fourth place.
Manager-less Huddersfield host Manchester City with the champions looking to keep the pressure on Liverpool at the summit of the Premier League.
Ole Gunnar's first home game in-charge of Manchester United ended in a 3-1 win over Huddersfield Town, with Paul Pogba the star of the show
David de Gea dons the armband for Manchester United, as Ole Gunnar Solskjaer takes charge of his first home game as the caretaker boss against Huddersfield Town
Unai Emery has chosen to field what potentially looks like a 3-5-2 formation, with Alexandre Lacazette and Pierre-Emerick Aubameyang leading the Arsenal attack.
A return to winning ways will be on the agenda for both Wolverhampton Wanderers and Huddersfield Town when they meet at Molineux on Sunday