Fred will replace Nemanja Matic, while Harry Maguire will be in contention to feature when Manchester United and Brighton & Hove Albion face off on Saturday.
Manchester United are looking to put their three-game winless streak behind them as they play hosts to Brentford on Monday.
Six players, including Jadon Sancho and Harry Maguire, have been ruled out as Manchester United get set to face Chelsea in the Premier League.
Raphael Varane replaces Harry Maguire in defence, while Cristiano Ronaldo, Scott McTominay and Jadon Sancho start for Manchester United against Arsenal.
Cristiano Ronaldo and Scott McTominay should return, while Harry Maguire is likely to be benched when Manchester United face Arsenal at the Emirates.
Thiago Alcantara ran the show while Mohamed Salah, Luis Diaz and Sadio Mane also shined as Liverpool thrashed Manchester United 4-0 at Anfield.
Manchester United legend Nemanja Vidic has suggested the club should consider taking Harry Maguire out of the lineup amid his poor run of form.
Paul Pogba and Harry Maguire are likely to start but Cristiano Ronaldo is a major doubt as Manchester United get set to take on Leicester City.
Former Netherlands international Rene van der Gijp insists Erik ten Hag should 'get rid of' three key Manchester United stars after taking over
Manchester United could reportedly let go of club captain Harry Maguire in the summer transfer window.
