Jose Mourinho debuts as Tottenham Hotspur manager for their visit to the London Stadium to take on West Ham United on Saturday.
Liverpool will be hoping to reopen their six-point gap atop the Premier League table when they welcome Tottenham to Anfield on Sunday.
Brighton will be hoping to take advantage of Tottenham's lousy form when they host the North London side at the Amex Stadium.
Mauricio Pochettino and his Tottenham side will be looking to end a miserable run of games to begin a new chapter against a travelling Southampton side
Tottenham Hotspur will host in-form Crystal Palace in the Premier League as Mauricio Pochettino looks to end a three-game winless run
Tottenham and Liverpool will lock horns on Saturday night in an all-English UEFA Champions League final at the Wanda Metropolitano Stadium.
Liverpool will be hoping to return to the top of the Premier League table when they host Tottenham Hotspur at Anfield in a crucial encounter for both sides.
Southampton hosts Tottenham with both sides hoping to bounce back from their difficult spell in recent games.
Real Madrid have been told to cough up a staggering £310 million if they are to secure the services of Harry Kane from Tottenham Hotspur.
After progressing from the Champions League group stages, Tottenham will be in high spirits when they host Burnley at Wembley and look for all three points