Unai Emery will be expecting a response from his team and in addition to Sokratis being back from suspension, there could be changes in midfield and attack.
Unai Emery rings in the changes as Xhaka and Koscielny are absent from the squad, while Aubameyang is only fit for the bench as Iwobi takes his place
Arsenal had a few injury concerns heading into the international break but will see a number of stars return to contention when they face Newcastle United.
Arsenal made a statement of intent for a top four spot with a convincing victory over Manchester United
Unai Emery has made just two changes to the Arsenal team that defeated Huddersfield Town, for the UEFA Europa League clash against BATE Borisov.
Mesut Ozil is one of seven changes made by Unai Emery from Arsenal's most recent game as the Gunners prepare to host Cardiff City at the Emirates.
Arsenal host an emotional Cardiff City at home, with Unai Emery's side hoping to build on their recent victory over Chelsea and keep the pressure on the Blues.
Arsenal responded to their defeat to Liverpool with a massive win over Fulham at the Emirates and moved within two points of Chelsea
Arsenal prepares themselves for their blockbuster, year ending clash with leaders Liverpool as the Gunners seek three points and keep pace with Chelsea
Arsenal travel to the Amex Stadium for their clash with Brighton as Unai Emery's men seek to keep pace with their their top-four rivals on the Premier League table