Fred will replace Nemanja Matic, while Harry Maguire will be in contention to feature when Manchester United and Brighton & Hove Albion face off on Saturday.
Juan Mata replaces Marcus Rashford while Fred is back on the bench as Manchester United face Brentford in the Premier League.
Fred is in line to return while there may be starts for youngsters Hannibal Mejbri and Alvaro Fernandez when Manchester United face Brentford.
Marcus Rashford is likely to replace Cristiano Ronaldo, while Fred and Raphael Varane remain unavailable for Manchester United against Liverpool.
Nemanja Matic and Paul Pogba will start, but Fred is unavailable due to an injury ahead of Manchester United's Premier League clash with Norwich City.
Cristiano Ronaldo exemplified Manchester United's problems again as the Red Devils played out a goalless draw with Watford on Saturday.
Fred could come in for Paul Pogba while Raphael Varane and Marcus Rashford could start when Manchester United take on Atletico Madrid.
Fred and Alex Telles could return to the starting lineup when Manchester United and Brighton & Hove Albion face off at Old Trafford on Tuesday.
Manchester United will be desperate to return to winning ways when they welcome Brighton & Hove Albion to Old Trafford on Tuesday.
David de Gea and Paul Pogba are set to start while Fred and Alex Telles are ruled out as Manchester United get set to face Burnley in the Premier League.