Claude Puel's well-drilled defense managed to keep the in-form Liverpool team from scoring in a frustrating outing for the Reds.
The Reds had to be satisfied with a point in a frustrating evening at the St. Mary's stadium.
Dutch midfielder Georginio Wijnaldum replaces the injured Adam Lallana in the playing XI, while summer signing Sofiane Boufal starts for the hosts.
Liverpool are reportedly preparing a January move for FC Rostov forward Sardar Azmoun as cover for Sadio Mane, who is set to be unavailable due to the African Cup of Nations.
Liverpool captain Jordan Henderson has heaped praised on the star-studded trio of Philippe Coutinho, Sadio Mane and Roberto Firmino
There was plenty action in the game week 11 of the Premier League, with Manchester City dropping points while Liverpool and Chelsea proving their title credentials by marching on to a dominating victory
Liverpool produced yet another attacking masterclass at the weekend at Selhurst Park to emerge victorious with a 4-2 scoreline but concerns remain at the back.
Liverpool emerged victorious in a topsy-turvy encounter away to Selhurst Park to keep level on points tally with Manchester City and Arsenal
Liverpool have their captain Jordan Henderson back but there are doubts over James Milner's fitness as Klopp prepares his side for the Crystal Palace tie.
An in-form Liverpool side travel to face Crystal Palace as Christian Benteke goes head-to-head against his former club.