Nicolas Pepe comes into the side for Gabriel Martinelli, while Dani Ceballos returns to the starting lineup as Arsenal get set to take on Newcastle United.
Hector Bellerin and Gabriel Martinelli are in contention to return while Dani Ceballos will start when Arsenal take on Leeds United in the FA Cup third round.
Arsenal will be hoping to book safe passage through to the FA Cup fourth round when they welcome Leeds United to the Emirates on Monday.
Arsenal will be without Dani Ceballos when they play Leicester City this weekend, but Pierre-Emerick Aubameyang and Mesut Ozil should be back in the starting XI
Arsenal once again failed to hold on to a lead as a late Bruno Duarte goal condemned them to a 1-1 draw against Vitoria SC in the UEFA Europa League.
Joe Willock comes into the side in place of Dani Ceballos as Arsenal prepare to take on Sheffield United at Bramall Lane.
Unai Emery has made wholesale changes ahead of his side's game against Bournemouth at the Emirates, with Dani Ceballos among those starting.
Unai Emery has made several changes from the team that played in the Europa League, although he retains Bukayo Saka for his first ever Premier League start.
Unai Emery has named Mesut Ozil in the side for the first time this season, while Granit Xhaka and Dani Ceballos start in midfield for Arsenal against Watford
Unai Emery will have to find a way to play his team without Alexandre Lacazette after the striker was ruled out for a month