Reece James and Andreas Christensen have both been handed starts in a crucial away game for Chelsea against Valencia in the Champions League.
Mateo Kovacic comes into the Chelsea starting lineup in place of Ross Barkley as the Blues prepare to take on Ajax in their third Champions League encounter.
Frank Lampard takes charge of his first Premier League game as the Chelsea manager against arch-rivals Manchester United at Old Trafford on Sunday.
Eden Hazard is on the bench, with Maurizio Sarri making seven changes to his most recent side as Chelsea prepare to take on Slavia Praha at the Eden Arena.
Gonzalo Higuain makes his Chelsea debut as part of a much changed side as the Blues gear up to face Sheffield Wednesday in the FA Cup at Stamford Bridge.
Olivier Giroud is among three changes made by Maurizio Sarri to the side that was beaten by Arsenal as Chelsea prepare to host Tottenham in the Carabao Cup semi-final.
Leon Bailey's stepfather Craig Butler has claimed that Chelsea have inquired about the young talent and that he is unhappy at Bayer Leverkusen.
Maurizio Sarri has made eight changes to the side that beat Nottingham Forest last week as Chelsea prepare to take on Tottenham in the Carabao Cup.
Chelsea starlet and Bayern Munich target Callum Hudson-Odoi is reportedly wanted by Italian champions Juventus as well as German outfit RB Leipzig.
Maurizio Sarri has rung in the changes to the side that was held to a goalless stalemate by Southampton, as Chelsea prepare to host Nottingham Forest in the FA Cup