Reece James is ruled out with a knee injury while Mateo Kovacic replaces Mason Mount in the Chelsea lineup for their home game against Arsenal.
Hector Bellerin is back in the Arsenal starting lineup, replacing Ainsley Maitland-Niles for their Premier League away game against Chelsea.
Arsenal are likely to welcome back defender Sokratis Papastathopoulos for their Premier League away game against Chelsea on Tuesday night.
Chelsea youngster Reece James is expected to be fit and available for selection when Arsenal come visiting for a Premier League fixture on Tuesday night.
Both Chelsea and Arsenal will be looking to return to winning ways when they take on each other in the London Derby on Tuesday night.
Liverpool are reportedly set to head-to-head with Chelsea in pursuit of Timo Werner, who is valued at £60 million by RB Leipzig.
Reece James was the only positive for Chelsea as they were defeated 1-0 by Newcastle United at the St. James' Park on Saturday evening.
Tottenham are reportedly plotting a raid on London rivals Chelsea for Brazilian winger Willian, who will be out of contract at the end of the season.
Inter Milan has been one of the most active clubs in the winter transfer window as Antonio Conte looks to strengthen his backline with a loan deal for Victor Moses.
N'Golo Kante is in contention to feature while Mateo Kovacic could come into the starting XI when Chelsea face off against Newcastle United this weekend.