Unai Emery has opted to bench Aaron Ramsey and has decided to retain Petr Cech in goal as Arsenal take on Chelsea at Stamford Bridge.
Mesut Ozil has returned to fitness in time as the German starts for Arsenal in the first-leg of the UEFA Europa League semi-final against Atletico Madrid.
Arsene Wenger has handed starts to both Jack Wilshere and Aaron Ramsey as Arsenal face CSKA Moscow in the UEFA Europa League.
Arsene Wenger will be boosted by the return of Petr Cech and Laurent Koscielny who are both in line to return to action as Middlesbrough host Arsenal.
Arsenal host Manchester City on Sunday evening in a crucial English Premier League fixture
Arsenal are reportedly plotting a January bid for Sunderland's highly-rated English goalkeeper Jordan Pickford.
Kieran Gibbs starts on the left side of the defence with Alex Oxlade-Chamberlain being Wenger's choice for left midfield. Xhaka is replaced by Coquelin, who partners Cazorla in the holding midfield role.
Arsenal are reportedly interested in Toulouse's 17-year-old French goalkeeping prodigy, but face competition from FC Porto and Juventus.
On Thursday, Arsenal and former Chelsea goalkeeper number one Petr Cech announced his retirement from international football.
Arsenal goal keeper Petr Cech has taken to twitter to express his anger at the results of Thursday's referendum, which resulted in majority of Britain voting to leave the European Union