Arsene Wenger will be boosted by the return of Petr Cech and Laurent Koscielny who are both in line to return to action as Middlesbrough host Arsenal.
Arsenal host Manchester City on Sunday evening in a crucial English Premier League fixture
Arsenal are reportedly plotting a January bid for Sunderland's highly-rated English goalkeeper Jordan Pickford.
Kieran Gibbs starts on the left side of the defence with Alex Oxlade-Chamberlain being Wenger's choice for left midfield. Xhaka is replaced by Coquelin, who partners Cazorla in the holding midfield role.
Arsenal are reportedly interested in Toulouse's 17-year-old French goalkeeping prodigy, but face competition from FC Porto and Juventus.
On Thursday, Arsenal and former Chelsea goalkeeper number one Petr Cech announced his retirement from international football.
Arsenal goal keeper Petr Cech has taken to twitter to express his anger at the results of Thursday's referendum, which resulted in majority of Britain voting to leave the European Union
Theo Walcott, Danny Welbeck and Petr Cech star in a recently released advertisement for a car rental company, and it provides the opportunity for Cech to express his inner Beyonce.
Arsenal face a crucial game in their Premier League campaign as they head to Goodison Park to take on Everton. However, the Gunners will be missing a few big names through injury.
Arsene Wenger's embattled Arsenal outfit face an uphill task as they head to the Camp Nou to lock horns with Luis Enrique's all conquering Barcelona side on Wednesday night.