Kieran Gibbs starts on the left side of the defence with Alex Oxlade-Chamberlain being Wenger's choice for left midfield. Xhaka is replaced by Coquelin, who partners Cazorla in the holding midfield role.
Arsenal are reportedly interested in Toulouse's 17-year-old French goalkeeping prodigy, but face competition from FC Porto and Juventus.
On Thursday, Arsenal and former Chelsea goalkeeper number one Petr Cech announced his retirement from international football.
Arsenal goal keeper Petr Cech has taken to twitter to express his anger at the results of Thursday's referendum, which resulted in majority of Britain voting to leave the European Union
Theo Walcott, Danny Welbeck and Petr Cech star in a recently released advertisement for a car rental company, and it provides the opportunity for Cech to express his inner Beyonce.
Arsenal face a crucial game in their Premier League campaign as they head to Goodison Park to take on Everton. However, the Gunners will be missing a few big names through injury.
Arsene Wenger's embattled Arsenal outfit face an uphill task as they head to the Camp Nou to lock horns with Luis Enrique's all conquering Barcelona side on Wednesday night.
The biggest North London derby in recent years approaches, and Arsenal find themselves short of one world class goalkeeper. Tottenham, on the other hand, have received a boost with two players returning from injury.
When a bitter personal rivalry takes on a more significant picture in the title race, then sparks will fly. This North London derby promises to be one of the most rollicking encounters that we will see this season.
Petr Cech sustained a calf injury in the dying stages of Arsenal's 2-1 defeat to Swansea City, with Arsene Wenger confirming that the setback will see him sidelined for at least three to four weeks.